TrkC Antibody
TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3) . Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:100, Western blot: 1:1000
UniProt
Q16288
Host
Rabbit
Reactivity
Human
Immunogen
This TrkC antibody was produced from rabbits immunized with a his tag recombinant protein of human TrkC.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TrkC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TrkC antibody is available for research use only.
Storage Conditions
Aliquot the TrkC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TrkC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC analysis of FFPE human brain section using TrkC antibody; Ab was diluted at 1:100.
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