TrkA Antibody / NTRK1
TRKA (also known as NTRK1) is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
P04629
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 769-796 from the human protein was used as the immunogen for this TrkA antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TrkA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TrkA antibody is available for research use only.
Storage Conditions
Aliquot the TrkA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TrkA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of TrkA antibody and HepG2 lysate. Observed molecular weight: 85~140 kDa depending on glycosylation level.
Documents
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