TrkA Antibody / NTRK1
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Isoform 3 is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. [Isoform 3 information courtesy of UniProt].
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50
UniProt
P04629
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the TrkA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TrkA antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the TrkA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Prediction Reactivity
Rat, Chicken
Image Legend
Western blot analysis of TrkA antibody and mouse liver tissue lysate. Observed molecular weight: 85~140 kDa depending on glycosylation level.
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