TIE2 Antibody / TEK
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunohistochemistry (Paraffin) : 1:50-1:100
UniProt
Q02763
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 758-789 from the human protein was used as the immunogen for this TIE2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TIE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TIE2 antibody is available for research use only.
Storage Conditions
Aliquot the TIE2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TIE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine
Image Legend
Western blot analysis of TIE2 antibody and 293 cell lysate either nontransfected (Lane 1) or transiently transfected with the TEK gene (2) .
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