RET Antibody
RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P07949
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1012-1042 from the human protein was used as the immunogen for this RET antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This RET antibody is available for research use only.
Storage Conditions
Aliquot the RET antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the RET antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of RET antibody and 293 cell lysate either nontransfected (Lane 1) or transiently transfected with the RET gene (2) .
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