KDR Antibody / Kinase Insert Domain Receptor / VEGFR2

KDR is a major growth factor for endothelial cells. This protein encodes one of the two receptors of the KDR. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc..

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000, Flow Cytometry: 1:10-1:50

UniProt

P35968

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 1153-1182 from the human protein was used as the immunogen for this KDR antibody.

Clonality

Polyclonal

Isotype

Applications

WB, FACS, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the KDR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This KDR antibody is available for research use only.

Storage Conditions

Aliquot the KDR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the KDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Location

Cytoplasmic and cell surface

Image Legend

Western blot analysis of KDR antibody and mouse lung tissue lysate. Predicted molecular weight: ~152 (immature), 180-200 kDa (intermediate) and 220-230 kDa (mature) .