ErbB2 Antibody
ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An Interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50, IHC (Paraffin) : 1:50-1:100
UniProt
P04626
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 21-52 from the human protein was used as the immunogen for this ErbB2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ErbB2 antibody is available for research use only.
Storage Conditions
Aliquot the ErbB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat
Image Legend
Western blot analysis of ErbB2 in T47D cell lysate, either noninduced (Lane 1) or induced with HRG (2) .
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