ApoE Antibody (Apolipoprotein E)
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
P02649
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 263-292 from the human protein was used as the immunogen for this ApoE antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ApoE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ApoE antibody is available for research use only.
Storage Conditions
Aliquot the ApoE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ApoE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate, Rabbit
Location
Cytoplasmic, membranous
Image Legend
Western blot analysis of lysate from human plasma tissue lysate using ApoE antibody diluted at 1:1000. Predicted molecular weight: 34-37 kDa
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