DYRK1A Antibody
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000, IHC (Paraffin) : 1:50-1:100
UniProt
Q13627
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 107-136 from the human protein was used as the immunogen for this DYRK1A antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DYRK1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DYRK1A antibody is available for research use only.
Storage Conditions
Aliquot the DYRK1A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the DYRK1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat, Xenopus
Image Legend
Western blot testing of DYRK1A antibody at 1:2000 dilution. Lane 1: mouse brain lysate; 2: HeLa lysate; Predicted molecular weight ~ 85 kDa.
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