p38 Antibody (MAPK14)
P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Product Specifications
UniProt
Q16539
Host
Rabbit
Immunogen
A portion of amino acids 295-324 from the human protein was used as the immunogen for this p38 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IF, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p38 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p38 antibody is available for research use only.
CAS Number
9007-83-4
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