Tyrosinase Antibody
TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The protein has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this protein result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Immunofluorescence: 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
P14679
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 486-513 from the human protein was used as the immunogen for this Tyrosinase antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Tyrosinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tyrosinase antibody is available for research use only.
Storage Conditions
Aliquot the Tyrosinase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Tyrosinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Tyrosinase antibody immunohsitochemistry analysis in formalin fixed and paraffin embedded human skin tissue.
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