Anti-NLRP12 Antibody
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD) . NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P59046
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This anti-NLRP12 antibody was produced from rabbits immunized with human NLRP12 recombinant protein.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the anti-NLRP12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This anti-NLRP12 antibody is available for research use only.
Storage Conditions
Aliquot the anti-NLRP12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the anti-NLRP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of anti-NLRP12 antibody and HL-60 lysate. Predicted molecular weight: ~119kDa, routinely observed at 100~119kDa.
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