AMPK alpha 2 Antibody (PRKAA2)
AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). It acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. [UniProt]
Product Specifications
CAS Number
9007-83-4
UniProt
P54646
Host
Rabbit
Immunogen
A portion of amino acids 476-507 from the human protein was used as the immunogen for this AMPK alpha 2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the AMPK alpha 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AMPK alpha 2 antibody is available for research use only.
Documents
Frequently Asked Questions
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