Tuberin Antibody
Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Product Specifications
UniProt
P49815
Host
Rabbit
Immunogen
A portion of amino acids 1776-1805 from the human protein was used as the immunogen for this Tuberin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Tuberin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tuberin antibody is available for research use only.
CAS Number
9007-83-4
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