Tuberin Antibody
Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:10-1:50, Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
P49815
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1776-1805 from the human protein was used as the immunogen for this Tuberin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Tuberin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tuberin antibody is available for research use only.
Storage Conditions
Aliquot the Tuberin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Tuberin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from SH-SY5Y, MCF-7, PC3, LNCaP, HeLa, cell line (left to right) using Tuberin antibody at 1:1000 for each lane.
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