GRB2 Antibody
GRB2 is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProt]
Product Specifications
UniProt
P62993
Host
Rabbit
Immunogen
A portion of amino acids 89-118 from the human protein was used as the immunogen for this GRB2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the GRB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GRB2 antibody is available for research use only.
CAS Number
9007-83-4
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