mTOR Antibody (FRAP1)
FRAP1/mTOR belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. It is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Product Specifications
UniProt
P42345
Host
Rabbit
Immunogen
A portion of amino acids 2459-2488 from the human protein was used as the immunogen for this mTOR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the mTOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This mTOR antibody is available for research use only.
CAS Number
9007-83-4
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