Rb Antibody / Retinoblastoma
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (Rb) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
P06400
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 586-615 from the human protein was used as the immunogen for this Rb antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Rb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Rb antibody is available for research use only.
Storage Conditions
Aliquot the Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Rb antibody immunohsitochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma.
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Saccharomyces cerevisiae Mitochondrial protein import protein ZIM17 (ZIM17)
Recombinant Saccharomyces cerevisiae Mitochondrial protein import protein ZIM17 (ZIM17)
Recombinant Saccharomyces cerevisiae Mitochondrial protein import protein ZIM17 (ZIM17)
Recombinant Saccharomyces cerevisiae Mitochondrial protein import protein ZIM17 (ZIM17)
Recombinant Saccharomyces cerevisiae Mitochondrial protein import protein ZIM17 (ZIM17)