LRP6 Antibody
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
O75581
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LRP6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LRP6 antibody is available for research use only.
Storage Conditions
Aliquot the LRP6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LRP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of LRP6 antibody and 293 cell lysate either nontransfected or transiently transfected with the LRP6 gene.
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