Leptin Receptor Antibody / LEPR / Ob-R
Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR) . LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50, IHC (Paraffin) : 1:50-1:100
UniProt
P48357
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 23-52 from the human protein was used as the immunogen for this Leptin Receptor antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Leptin Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Leptin Receptor antibody is available for research use only.
Storage Conditions
Aliquot the Leptin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Leptin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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