P-Glycoprotein Antibody
The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P08183
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the P-Glycoprotein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This P-Glycoprotein antibody is available for research use only.
Storage Conditions
Aliquot the P-Glycoprotein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the P-Glycoprotein antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
P-Glycoprotein antibody western blot analysis in K562 lysate. Expected molecular weight: 141-180 kDa depending on glycosylation level.
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