NPM1 Antibody
Nucleophosmin/NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF. NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:10-1:50, Western blot: 1:1000, Flow Cytometry: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
P06748
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 198-226 from the human protein was used as the immunogen for this NPM1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IHC, WB, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NPM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NPM1 antibody is available for research use only.
Storage Conditions
Aliquot the NPM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NPM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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