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IRF8 Antibody

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000, Flow Cytometry: 1:10-1:50

UniProt

Q02556

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 384-409 from the human protein was used as the immunogen for this IRF8 antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

FACS, WB, ELISA

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the IRF8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This IRF8 antibody is available for research use only.

Storage Conditions

Aliquot the IRF8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the IRF8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

IRF8 antibody flow cytometric analysis of HL-60 cells (green) compared to a negative control (blue) . FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.

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