FOXP3 Antibody
Forkhead box P3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) . Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) . [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
Q9BZS1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 283-311 from the human protein was used as the immunogen for this FOXP3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the FOXP3 antibody and store frozen at -20oC or colder.
Limitations
This FOXP3 antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the FOXP3 antibody and store frozen at -20°C or colder.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Prediction Reactivity
Primate
Image Legend
FOXP3 antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram) .
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