KLF4 Antibody

Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

O43474

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 20-53 from the human protein was used as the immunogen for this KLF4 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the KLF4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This KLF4 antibody is available for research use only.

Storage Conditions

Aliquot the KLF4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the KLF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

KLF4 antibody western blot analysis in (1) HeLa, (2) MCF-7 and (3) SW480 lysate. Predicted molecular weight: 50-60 kDa + possible ~75 kDa (phosphorylated form) .