ACSL6 Antibody
FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL) . It is characterized by a chromosomal translocation t (5;12) (q31; p13) that involves ETV6 and ACSL6.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9UKU0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 240-270 from the human protein was used as the immunogen for this ACSL6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ACSL6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ACSL6 antibody is available for research use only.
Storage Conditions
Aliquot the ACSL6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ACSL6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
FACL6 antibody used in western blot to detect FACL6 in mouse liver tissue lysate
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