MARCKS Antibody
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P29966
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 241-271 from the human protein was used as the immunogen for this MARCKS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MARCKS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MARCKS antibody is available for research use only.
Storage Conditions
Aliquot the MARCKS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MARCKS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of MARCKS antibody and HeLa lysate. Predicted molecular weight ~32 kDa.
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