CHK1 Antibody

Checkpoint kinase 1, commonly referred to as CHK1 is an serine/threonine-specific protein kinase that in humans, is encoded by the CHEK1 gene. CHK1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

O14757

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 258-287 from the human protein was used as the immunogen for this CHK1 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Store at 4oC for up to one month. For long term, aliquot the CHK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This CHK1 antibody is available for research use only.

Storage Conditions

Store at 4°C for up to one month. For long term, aliquot the CHK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the CHK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.