Mib1 Antibody
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Product Specifications
UniProt
Q86YT6
Host
Rabbit
Immunogen
A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC, WB, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Mib1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Mib1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680750/datasheet/f47999-0.4ml.pdf
CAS Number
9007-83-4
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