p65 Antibody
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivates NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs. [OMIM]
Product Specifications
UniProt
Q04206
Host
Rabbit
Immunogen
A portion of amino acids 32-60 from the human protein was used as the immunogen for this p65 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p65 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p65 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680582/datasheet/f47588-0.4ml.pdf
CAS Number
9007-83-4
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