APC Antibody / Adenomatous polyposis coli
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P25054
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 1148-1176 from the human protein was used as the immunogen for this APC antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the APC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This APC antibody is available for research use only.
Storage Conditions
Aliquot the APC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the APC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
APC antibody western blot analysis in mouse heart tissue lysate
Frequently Asked Questions
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