XRCC4 Antibody
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq].
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q13426
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 205-234 from the human protein was used as the immunogen for this XRCC4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the XRCC4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This XRCC4 antibody is available for research use only.
Storage Conditions
Aliquot the XRCC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the XRCC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear
Image Legend
XRCC4 antibody western blot analysis in A549 lysate. Predicted molecular weight: 35-38/55 kDa (unmodified/phosphorylated) .
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