NLRP4 Antibody
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD) . NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q96MN2
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 121-149 from the human protein was used as the immunogen for this NLRP4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the NLRP4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NLRP4 antibody is available for research use only.
Storage Conditions
Aliquot the NLRP4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NLRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
NLRP4 antibody western blot analysis in uterus tissue lysate.
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