RBPJ Antibody / RBP-JK
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000, IHC (Paraffin) : 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
Q06330
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1-29 from the human protein was used as the immunogen for this RBPJ antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the RBPJ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This RBPJ antibody is available for research use only.
Storage Conditions
Aliquot the RBPJ antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the RBPJ antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of RBPJ antibody at 1:2000 dilution and 1) Ramos, 2) human pancreas lysate; Predicted molecular weight ~ 56 kDa.
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