Src Antibody
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P05480
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 98-125 from the mouse protein was used as the immunogen for this Src antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Src antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Src antibody is available for research use only.
Storage Conditions
Aliquot the Src antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Src antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Src antibody western blot analysis in mouse liver tissue lysate.
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