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Src Antibody

Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.

Product Specifications

UniProt

P05480

Host

Rabbit

Immunogen

A portion of amino acids 98-125 from the mouse protein was used as the immunogen for this Src antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

WB, ELISA

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Src antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Src antibody is available for research use only.

Product Datasheet

https://cdn.gentaur.com/products/800/6680255/datasheet/f45526-0.08ml.pdf

CAS Number

9007-83-4

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