REST Antibody
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q13127
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the REST antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This REST antibody is available for research use only.
Storage Conditions
Aliquot the REST antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the REST antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
REST antibody western blot analysis in Jurkat lysate.
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