REST Antibody
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Product Specifications
UniProt
Q13127
Host
Rabbit
Immunogen
A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the REST antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This REST antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680205/datasheet/f45229-0.08ml.pdf
CAS Number
9007-83-4
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