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PCSK4 Antibody

Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405) . Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]) .[supplied by OMIM].

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

Q6UW60

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 168-196 from the human protein was used as the immunogen for this PCSK4 antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS pH 7.4 with 0.09% sodium azide

Reconstitution

Aliquot the PCSK4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This PCSK4 antibody is available for research use only.

Storage Conditions

Aliquot the PCSK4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the PCSK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

PCSK4 antibody western blot analysis in SK-BR-3 lysate.

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