Leptin Antibody
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq].
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry (Paraffin) : 1:10-1:50, Flow cytometry: 1:10-1:50
UniProt
P41159
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 8-37 from the human protein was used as the immunogen for this LEP antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LEP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LEP antibody is available for research use only.
Storage Conditions
Aliquot the LEP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LEP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
LEP antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue.
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