MCM7 Antibody
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P33993
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 290-318 from the human protein was used as the immunogen for this MCM7 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MCM7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MCM7 antibody is available for research use only.
Storage Conditions
Aliquot the MCM7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MCM7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
MCM7 antibody western blot analysis in Jurkat lysate.
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