L1CAM Antibody / NCAM-L1 / CD171
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000 (1)
UniProt
P32004
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This L1CAM antibody is available for research use only.
Storage Conditions
Aliquot the L1CAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Prediction Reactivity
Rat
Image Legend
L1CAM antibody western blot analysis in mouse cerebellum tissue lysate. Expected molecular weight of glycosylated protein is 200-240 kDa.
Frequently Asked Questions
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