TLR6 Antibody
TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow Cytometry: 1:10-1:50, Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9Y2C9
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 393-423 from the human protein was used as the immunogen for this TLR6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TLR6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TLR6 antibody is available for research use only.
Storage Conditions
Aliquot the TLR6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TLR6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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