TLR6 Antibody
TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Product Specifications
UniProt
Q9Y2C9
Host
Rabbit
Immunogen
A portion of amino acids 393-423 from the human protein was used as the immunogen for this TLR6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, WB, IHC, ELISA
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the TLR6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TLR6 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680079/datasheet/f44376-0.08ml.pdf
CAS Number
9007-83-4
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