Pak4 Antibody
Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50
UniProt
Q8BTW9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 187-216 from the mouse protein was used as the immunogen for this Pak4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Pak4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Pak4 antibody is available for research use only.
Storage Conditions
Aliquot the Pak4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Pak4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Pak4 antibody western blot analysis in mouse Neuro-2a lysate
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