CDKN2B Antibody
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P42772
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 103-131 from the human protein was used as the immunogen for this CDKN2B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CDKN2B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CDKN2B antibody is available for research use only.
Storage Conditions
Aliquot the CDKN2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CDKN2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
CDKN2B antibody western blot analysis in CEM lysate
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