MAVS Antibody
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA and IKKB which activate NFKB, or TBK1 and IKKE (IKBKE; MIM 605048), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB. For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF. For RIGI, the intermediary protein is mitochondria-bound IPS1.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q7Z434
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 477-505 from the human protein was used as the immunogen for this MAVS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MAVS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MAVS antibody is available for research use only.
Storage Conditions
Aliquot the MAVS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MAVS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
MAVS antibody western blot analysis in HeLa lysate. Predicted molecular weight: 51-54 kDa (cleaved), 57 kDa (unmodified), 75 kDa (aggregated) .
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