HDAC4 Antibody
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
P56524
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1049-1077 from the human protein was used as the immunogen for this HDAC4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HDAC4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HDAC4 antibody is available for research use only.
Storage Conditions
Aliquot the HDAC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HDAC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nucleus
Image Legend
HDAC4 antibody western blot analysis in NCI-H292 lysate. Expected molecular weight: ~140 kDa (full length), ~95 kDa (truncated) .
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