Puma Antibody
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Product Specifications
UniProt
Q9BXH1
Host
Rabbit
Immunogen
A portion of amino acids 119-154 (BH3 domain) from the human protein was used as the immunogen for this Puma antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, FACS, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Puma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Puma antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6679580/datasheet/f42785-0.4ml.pdf
CAS Number
9007-83-4
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