Ar-Turmerone

Ar-Turmerone ((+) -ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study[1][2][3][4][5].

Product Specifications

CAS Number

[532-65-0]

Product Name Alternative

(+) -ar-Turmerone

UNSPSC

12352005

Hazard Statement

H317, H319, H411

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ar-turmerone.html

Purity

99.00

Solubility

Ethanol : 50 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)[C@H](CC(/C=C(C)\C)=O)C

Molecular Formula

C15H20O

Molecular Weight

216.32

Precautions

H317, H319, H411

References & Citations

[1]Liju VB, et al. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J Pharmacol. 2011 Sep;43 (5) :526-31.|[2]Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48 (8-9) :2011-20.|[3]Lee Y, et al. Activation of apoptotic protein in U937 cells by a component of turmeric oil. BMB Rep. 2009 Feb 28;42 (2) :96-100.|[4]Yonggang T, et al. Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR) . Hum Vaccin Immunother. 2012 Oct;8 (10) :1416-24.|[5]Zhou W, et al. Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model. Bioorg Med Chem. 2025 Jan 1;117:118014.