Bak Antibody
BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Western blot: 1:1000
UniProt
Q16611
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 56-91 from the human protein was used as the immunogen for this Bak antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Bak antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Bak antibody is available for research use only.
Storage Conditions
Aliquot the Bak antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Bak antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC analysis of FFPE hepatocarcinoma cancer tissue stained with the Bak antibody
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